IMM250H1 Lecture Notes - Lecture 1: Cowpox, Neutrophil, Apoptosis
Document Summary
Lecture 1 - the immune system: from historical to modern perspectives. A system of tissue, cells and soluble factors that recognize, attack and destroy. Does cowpox convey protective immunity against smallpox. Pasteur: use attenuated cholera induce acquired immunity in chickens expand to rabies vaccines are born! Human wbc engulf and destroy pathogens like bacteria. Later, landsteiner: wbc transfer tuberculin immunity. Von behring & shibasaburo: serum from guinea pigs inoculated with diphtheria protected against lethal doses. 2. binding lead to release of more receptors. Frank macfarlane burnet - revision of ehrlich"s theory. Each antibody is the specific product of a cell, that product is presented on the cell surface. Antigen reacts with any cell that has the receptor activation of the cells to proliferate. Difference from ehrlich: each lymphocyte makes only one kind of antibody. E. g. cytotoxicity , apoptosis of virally infected cells. Pre-existing antibodies bloss access of virus to receptor.
