IMM250H1 Lecture Notes - Lecture 4: Lymph Node, Mast Cell, Natural Killer Cell

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29 Nov 2018
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Lecture 4 - the acute inflammatory response: cellular and humoral mediators of innate defense. Phagocytosis, cytokine, apc (bridge between adaptive and innate!) Express prr that recognize opsonin (receptor - ligand) Complement r, fc r - pathogen opsonized tih c3b. Travel to lymph node present to t cells. High b7 on their surface: neutrophils ( granulocytes) Enter tissue,s use prr, injest and kill. Dna strand with toxic molecule from net (neutrophil extracellular trap: other granulocytes. Eosinophil, basophil, mast cell (not classified as granulocytes because not found in the blood and precursor unknown) Fast because their fcr are pre-loaded with ige. Chronic granulomatous disease (defects in bac killing ) Mutation in nadph oxidase can"t generate ros can"t kill bacteria. Feature: pleiotropy ( one many response); functional redundancy; synergy (mutually reinforce) Selectin - sugar (sialyl lewis) ( rolling) Opsonin in the lung uptake of bacteria. C1q is a bridge between innate and adaptive because it can bind antibodies.

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