IMM250H1 Lecture Notes - Lecture 8: Antimicrobial Peptides, Dendritic Cell, Microvillus
Document Summary
Mucosal system need to determine whether antigen id innocuous or harmful physiologic information (low level) that. System activates dendritic cells trigger adaptive immunity. All barriers are linked by one or more epithelial cells. Secret amp: antimicrobial peptides kill bacteria; some have cilia sweep bac away. Damaged epithelium send signal to immune cells initiate response. The intestinal epithelial layer comprises several specialized cells. Paneth: produce antimicrobial peptide e. g. amp, defensins. The intestinal epithelial stem cells (iesc) controls renewal o cell layer. Extended structure and heavy glycosylation makes mucus thick. Enterocyte produce surface bound mucins glycocalyx. Trap bacterial that penetrated the gel-like mucus. Transport antigens from intestinal lumen into submucosal place (basolateral) Allow activation of the lymphocyte to antigen or induction of tolerance. Immune cells: epi, dc, mo, innate lmphoid, bt lymphocytes. Eventually go directly to mesenteric ln. Epithelial cells, dendritic cells, macrophages, innate lymphoid cells, and b and t lymphocytes. Barrier tissues are served by local lymph node.
