20 best answer questions, 20 multiple choice questions ** Life span of conventional b cells determined by recirculation lecture 5. During selection process, they encounter self antigens within bone marrow which is where b development takes place. After development, b cells go through negative selection process: b cells highly reactive with antigens, eliminated by clonal deletion or receptor editing process. B cell receptors crosslinked by strongly interactive self-antigens. Also situation in which b cell receptor recognize self antigen but it s affinity, not strong enough to induce neither clonal deletion or editing process: soluble self-antigen, diff from mature b cells. Induce bit of activation result in different outcome, anergy. co-expression of igm and igd is sign of mature, naive b cell. anergic cells do migrate to periphery but express low levels of igm, cannot respond to antigen even when t cell help is provided. active process of rendering cells unable to respond to antigen.