Notes taken during lecture

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19 Dec 2011
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Do not recognizd peptide antigen presented by mhc class one or two recognize lipid antigen presented by cd1, one particular isoform of cd1 called cd1d. Limited limited tcr repertoire unique tcr alpha chain sequence all alpha chains in body same. Limited diversity on beta side in humans, only one v beta chain, 11, mouse can only use some of 20 or so in genome very restricted tcr repertoire. Functions very fast, in matter of minutes to hours (days for tcr?) can produce cytokines and chemokines . Can be protective or deleterious functions because of large array of functions, seem to be able to in vivo to selectively produce on type of cytokines, but not other unknown how achieve this . Cd1d must have something in binding groove otherwise cannot fold properly, cannot go to cell surface. Fit with self lipids, large collection of, - in steady state, do not respond to this lipid otherwise, autoimmunity.

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