IMM250H1 Lecture : Notes taken during lecture
Document Summary
Different barriers prevent body from being infected by different microorganisms. What happens if the microorganisms break through barriers. signal downstream to activate these transcription factors nfkappab. These transcriptioni factors produce mediators in inflammatory response to get ride of infection. also talked about damps: indogenous -released from dead or dying cells, detected by nlrp, once detected, also signal transduction response, activates protein complex called inflammasome, active inflammasome can process cytokines, controls i l-1beta. cells involved in killing bacteria and microorganisms. secreted mediators of the innate system: or they kill or protect. bacteria, fungus, viruses come into contact with gut cells. epithelial cells thus activated change gene profile to activate things that will kill bacteria. cell secretes the mediators involved in getting rid of bacteria. mediators called cytokines and chemokines: these call for reinforcements, thus inflammation physiological feel.
