Ehrlich discovered mast cells, mediators of allergic disease. handful of common ones and some rare disease. sterorids general suppression of immune system not specific, with sideeffects: some temporary disease relief, commonly used, etiology cause is unclear. women more effected: striking during child-bearing years. a lot of funding to this area. multi-systemic often kidney targeted systemic lupus. others have no gender bias, like diabetes. reason is unclear as to the female bias. Type 1 diabetes targeting insulin secreting cells of pancreas. rheumatoid arthritis multiple joints throughout body. scleroderma all over body, the skin. systemic lupus erythematosus lupus involvement of antibodies: antibodies access sites as they circulate the body, so multiple sites are accessed. how t cells lose their tolerance to self www. notesolution. com. T cell becomes activated and leads to autoimmune disease.