IMM250H1 Lecture Notes - Rodent, Autoimmune Polyendocrine Syndrome Type 1, Nuclear Material

46 views12 pages
15 Mar 2011
School
Department
Course
Professor

Document Summary

Ehrlich discovered mast cells, mediators of allergic disease. handful of common ones and some rare disease. sterorids general suppression of immune system not specific, with sideeffects: some temporary disease relief, commonly used, etiology cause is unclear. women more effected: striking during child-bearing years. a lot of funding to this area. multi-systemic often kidney targeted systemic lupus. others have no gender bias, like diabetes. reason is unclear as to the female bias. Type 1 diabetes targeting insulin secreting cells of pancreas. rheumatoid arthritis multiple joints throughout body. scleroderma all over body, the skin. systemic lupus erythematosus lupus involvement of antibodies: antibodies access sites as they circulate the body, so multiple sites are accessed. how t cells lose their tolerance to self www. notesolution. com. T cell becomes activated and leads to autoimmune disease.