IMM250H1 Lecture 3: Lecture 3
Document Summary
Lecture 3: innate recognition of microbes prrs, pamps, damps (once pathogen enters body/crosses initial barriers) Cells are immediately active as soon as they detect pathogen. Innate and adaptive immunity work together in humans; innate immunity initiates. Provides memory of infection when challenged by pathogen again responds much more efficiently. Pamps/mamps: non self adaptive; absence of adaptive immunity infection is initially controlled but cannot be cleared by innate immunity. Signatures of microbial infection-pieces of microbes parasites) typically not found in host cells; cell wall of bacteria are examples of pamps. Represent conserved chemical structure common to groups of microbes (bacteria, fungi, Bacteria can be differentiated into two groups based on gram stain or cell wall gram +, gram . Gram + thick peptidoglycan layer (retains crystal violet of gram stain) Gram - (e. coli) think lipopolysaccharides (endotoxin) or lps *** polysaccharides/pepti form the cell wall**
