IMM250H1 Lecture 11: Lecture 11
Document Summary
Dysfunctions of immunity: overly active or misdirected immune responses, immunodeficiency. Cytokine storm septic shock, avian flu, sars; allergies/asthma; autoimmune diseases (diabetes, multiple sclerosis, crohn"s disease) Primary (genetic) loss of immune function; secondary (acquired) loss of immune function; opportunistic infection (oral thrush) can occur in people with impaired immune responses; Sirs (systematic inflammatory syndrome; can be infectious or non-infectious) elevation of two or more of temperature, pulse, respiratory rate, wbc count. Severe sepsis associated with organ dysfunction, decreased perfusion, and hypotension. Septic shock sepsis-induced hypotension despite fluid replacement treatments blood flow abnormalities; multiple organ failure may occur. Septic shock can result from severe sepsis: unrestrained whole-body inflammation leads to: 50% mortality rate (higher then heart attack) Decreased perfusion (blood flow) and oxygen delivery to organs and tissues. Vatican died from septic shock and heart failure brought on by urinary tract infection. Older adults and young children account for majority sepsis cases.
