IMM250H1 Lecture Notes - Lecture 1: Innate Immune System, Gut Flora, Urinary Tract Infection
Document Summary
Lecture 1 the immune system: a historical perspective. The black death (bubonic plague) is one of the deadliest pandemics in human history: responsible for killing 30-60% of all europeans from 1350-1400 which didn"t recover until 1550, thought to be spread through trade routes. Renaissance they had a vast abundance of resources. 2000 bc the babylonian epic of gilgamesh documentation of disease and pestilence: thucydides reported the concept of immunity after exposure to disease during a plague outbreak in 430. 1500s fracastoro proposed a model to explain contagion suggested that contagious particles transmitted disease even over long distances wrongly thought that immunity to measles conferred immunity to smallpox. 1717 mary mortley montagu did some unethical experiments in which prisoners and children were inoculated with smallpox and where later exposed to smallpox she observed that none of the inoculated individuals contracted smallpox.
