IMM250H1 Lecture Notes - Lecture 1: Neutrophil Extracellular Traps, Innate Immune System, Interleukin 1 Beta
Document Summary
Innate immunity: cellular and humoral mediators of defense. In ammasome activates caspase 1 into an enzymatically active protein. Nlrp3 in ammasome involves nlpr3 conjugation with asc, with procaspase-1 laments, leading to cleavage. Active capsase 1 then cleaves pro-il-1b into il-1b, which is then secreted from the cell. Releases pamps, but these are detected by tlr/nod proteins activate signal transduction, activates nfkb and controls cytokine production. Releases damps, but these are detected by nlrp, activates signal transduction, in ammasome, controls il-1b production. Innate immune mediators: both cellular and humoral cells of the innate system and secreted mediators (can be protective unlike the cells) Pathogen with pamps, damages the epithelium and breaks through the epithelial barrier. Epithelial cells are activated upon contact prrs are triggered, nfkb, caspase 1 are activated. Mediators of innate immune defense are produce by activated epithelial cells (cytokines, chemokines that call in for reinforcements) In ammation = heat + swelling +redness + pain + loss of function.
