IMM340H1 Lecture 10: Lecture 10
Document Summary
Induce changes in differentiation state, proliferation, survival (or death) of target cells. Il-1, tnf- , cxcl8 (attracts neutrophils to sites of infections: secreted by cells of innate immunity (e. g. dendritic cells, macrophages, adaptive immunity cytokines. Il-2, il-4, il-17, ifn- : secreted by t and b lymphocytes. Cytokines can mediate the activation, proliferation, and differentiation of target cells: pleiotropy they can have multiple effects on different cell types. Il-4 secreted by th2 cells can act on different cell types: redundancy different cytokines might have the same effect on the same cells. Il-2, il-4, il-5 are all able to induce b cell proliferation: synergy when two cytokines act together and their combined effect is greater than their single effects. Il-4 and il-5 together induce switching to ige isotype: antagonism one cytokine can inactivate the effect of another. Ifn- and il-4 antagonize each other during the process of.