IMM250H1 Lecture Notes - Interleukin 9, Interleukin 10, Macrophage Colony-Stimulating Factor
Document Summary
Il-6, il-11, osm, lif, cntf, g-csf, ifn- / , il019, epo. Tnf family of cytokines (tnf- , cd40l, fasl, opgl) Chemokines with c-term segment and sheets. Insulin-related have conserved 3 disulphide bonds linking 3 short -helices. Once jaks are active the tyrosine phosporylated sites become docks for stats. Shared receptor subunits usually mean similar signalling events. Requires abundant pathogen on mhc class ii with high affinity. Proinflammaotry (il-6 il-23) for th17 (from early infection dc) Na ve t cells do not respond to il-12 because it is only expressed after signalling event. Neutrophils, vascular endothelial, protein release, muscle proteolysis, cytokins. Secretion of sil01rii leads to selective response to il-1 . T cell differentiation factor- induction of ifn- and il-4. Some b cells and nk cells also respond. Resting nk only lymphocyte that relies on only + il-2rs for proliferation. B cells respond to il-2 mediated by high affinity receptors. Interloop of a-b helices : il-2r (low affinity)
