IMM250H1 Lecture Notes - Regulatory T Cell, Il-2 Receptor, Tacrolimus

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3 Jun 2013
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Cyclosporine mainstay of immunosuppressive regimen both inhibiting calcineurine, important because activated downsream of t cell receptor lead to dephosphorylation of nfat, what cyclosporine and ___ do is inhibit alcineurin. Downstream of il2 transcription working to inhibit il2 synthesis. Nephrotoxic very high levels will damage kidneys. Il2 receptor antibodies basiliximab binds to il2 receptor t cells require il2 to proliferate so inhibiting the t cells from proliferating. Treatment immunosuppression where some acgents acting in cell. Standard immunosuppression designed to give people lots of immunosuppression typically use this thymoglobulin, rabbit anti-human t cell antibody. Over first few days, get sevral doses of this medication, buys time, prevents terrible rejection. Some side-effects have infection, have cancers later. Takes a while for calcineurin inhibitors to start working. While giving this, either giving cyclosporine or tacrolimus reach therapeutic levels. Prednisone, mmf, tacrolimus tpical first year regimen.

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