IMM250H1 Lecture Notes - Tumor Antigen, Cancer Immunology, Nude Mouse
Document Summary
Final exam tend to do worse responsible for all the lecture material and the second half of the student presentations. Induce clinically effective antitumour responses: do not want antitumour immunity to attack normal cell just target cancer cells. Establish antitumour immunological memory: memory effect improve patients" quality of life multiple doses. Burnet thought that immune system should be able to see tumours . Stutman but his mice was nude mice later on, nude mice have lots of nk cells. Schreiber and others lack b, t, and nk cells demonstrated a difference using these mice. Immune status of mice induce tumour using carcinogen in both immunodeficient and immunocompetent mice watch mice day by day for tumour formation. Past that, see difference tumour formation in immunodeficient mice; after 120 days, tumours also start to form in immunocmpetent mice. Concluded that immune system can watch the tumour cells and suppress formation of tumours.
