IMM250H1 Lecture Notes - Endothelium, Cell Adhesion Molecule, White Blood Cell
Document Summary
Amoeba engulf pathogens to protect itself; a more developed organism with vascular system, the entire vascular system employed in inflammation. Adverse effects: tissue injury may depend on location of inflammation; ex. Inflammation in eye may have long-term consequences for vision; Inflammation can be a significant pathogenic component to diseases. Predominant leukocyte recruited is neutrophil; can have some neutrophils for chronic inflammation, but generally mononuclear monocytes, so when go into tissues, differentiate into macrophages or dendritic cells or lymphocytes. Acute is self-limiting so healing phase occurs after the acute response. Different morphological features of these cells histological sections. Neutorphils eosinophils segmented nucleus polymorphonuclear feature. Lymphocytes also mononuclear nucleus fewer vacuoles than monocytes. Biopsy acute inflammatory response chronic inflammatory response inflammatory response. Vascular changes in inflammation variety of different changes that occur in response to changes in vasculature. Recruitment of leukocytes occurs usually in interstitial and postcapillary venules.
