IMM250H1 Lecture Notes - Lecture 6: Anaphylaxis, Monomer, Epitope
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What happens when a t-lymphocyte"s receptor is binded to by an antigen: secretes cytokines and molecular killers. Is the antigen receptor repertoire larger than the amount of antigens: yes. Can b-cells express both kappa and lamda light chains: no; either or. What does a b-cell bound to an antigen need to secret antibodies(abs): message from helper t cell (th) What is the antigen presenting molecule called: mhc. What do th contain: cd4+ - glycoprotien. Why must help be linked to b cells: to avoid helping other b cells. How are t and b cell bounded: cd40l(th cell) and cd40(b cell) interaction. What happens when you inhibit cd40l: no ab secretion. What happens to the b cell after th help: becomes either a plasma or a memory b cell. Where are plasma b cells located: bone marrow, spleen, lymph nodes. What can plasma b cells do: secrete antibodies at a high rate.
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1. | In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon? | ||||||||||
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2. | Your chances of having the same MHC haplotype as your siblingare: | ||||||||||
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3. | Which of the following is the BEST example of self-MHCrestriction of T cells? | ||||||||||
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4. | MHC molecules: | ||||||||||
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5. | Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this? | ||||||||||
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6. | How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress? | ||||||||||
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7. | MHC polymorphisms tend to cluster: | ||||||||||
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8. | A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to: | ||||||||||
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9. | The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean? | ||||||||||
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10. | Which of the following is an example ofcross-presentation? | ||||||||||
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