IMM250H1 Lecture Notes - Stem Cell, Basophil, Eosinophil

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6 May 2014
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Rate of production = rate of loss. Release on maturity, controlled by expression of cell surface adhesion molecules. Multiple assembly lines in marrow to produce erthyrocytes, platelets, neutrophils, monocytes, eosinophils, basophils, b cells, t cells. 1x10^6 bm cells -> irradiated mouse -> bm, blood; mouse reconstitutes; number of precursor cells back to normal. 1x10^3 bm cells -> irradiated mouse -> 4/5 mice see no reconstitution; 1/5 mice see transient reconstitution; 1/20 mice see permanent reconstitution (all lineages) Clonal reconstitutions are multilineage, both sustained and transient. Bm -> irradiated mouse -> some sustained reconstitution. Stem cells regenerate whole tissue and also regenerates progeny that remain so fully functional stem cell. Inject single stem cell, labelled with transgene luciferate therefore can be detected by light. Stem cells localized to site of injection or spread throughout the body. Multiple outcomes: difference due to differences in program in cells injected. Hsc sustain long-term hematopoiesis, generate multiple lineages, self-renew, sustain self- renewal over time.

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