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Lecture 02HSC also gives rise to platelets and RBCsHSC doesnt become end cell stages immediately BUT through developmental check points Progressively more restricted Microenvironment of bone marrow including cell to cell contact and cytokines as mediators and regulators of growth and differnetiaiton of H precusors Clinical importanceability through bone marrow transfers to provide reconstitution of cell populations and ultimately the potential uses of stemm cell therapy and gene therapy Wide range of H tissues and tissues of immune system all around body Broadly categorized into two types of tissuesPrimary or central lympohid organsbone marrow in bones of body thymus essential for generation of T lymphocytes bone marrow source of progentiors of all H cells and bone marrow is site where B lymphocytes undergo development T and bone marrow are primary lympohid organs because where cells of immune system develop not where immune responses take placeSecondary lymphoid organs are the rest major ones are spleen lymph nodes scattered throughout body Spleen and lymph nodes are where immune responses take place Tonsils peyers patch appendix many lymphoid tissues associated with tissues lungs the tear ducts behind the eyewide range of lympohid tissues associated with wide range of parts of the body and taken together these are considered the secondary lympohid organsTightly regulatedstructure Lymph nodeartery feeding into LN and vein draining it providing LN with blood supply Vast majority of cells that enter LN just flows in and flows out Immune responses take place in outer mregions of LN the beige regions near artery Afferent lymphatic vesselsdrain local tissues of fulid and cells that can migrate into LN through afferent lymphatics and permeate through LN compartments Many cells acquired through AFL or artery or produced in LN by cell division must leave LN at some point and when leave they go out through the efferent LV Two ways in and two ways out Within LN compartments can see its divided into different regions Outer layer immediately underlies outer capsule is cortex containing B cells predominately Germinal centressites in which B cells are rapidly proliferating and undergoing maturation events required to convert B cell into active antibody secreting cell called plasma cellGerminal centres presence is indication of ongoing immune response
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