IMM250H1 Lecture : Notes taken during lecture
Document Summary
Resolved that if immunize balbc mouse with syngeneic spenocytes coated with tnp, able to generate killer cells, that did not kill balbc targets, did not kill these targets coated with np, etc. See prev lecture didn"t kill any c56 targets. From that concluded, that killer cells generated in this balbc immunized didn"t recognized tnp alone, rather recognized tnp in conjunction with mhc, suggested. Mhc proven to be important in restricting t cell funciton, by making another congenic animal, balbb, which is balbc crossed with c57. Proven that tnp had bound to every molecules, but the important molecule was mhc. Concluded that it is self mhc that is restricting function of t killer cells generated in either balbc or c57 black mouse. Killer cells not always cd8 positive cells; expression of cd4 and cd8 denote restriction specificity of that t cell, not its function.
