IMM250H1 Lecture : Notes taken during lecture
Document Summary
Pamp molecules generally only produced by microbial pathogens also essential for survival and pathogenicity of microbe so microbe cannot evolve away from these molecules recognized by innate immune system. Viruses express molecues that show huge variability; that result in adapative immune responses having specificity for one strain but not other strains these are not good targets for prr because they exhibit change. Collectin molecules particular carobhydrate linkages expressed in pathogenic world but not in higher organisms. Phagocytic cells like macrophages express receptors that recognize patterns mannose receptors that recognize bacteiral carbohydrate faciliate phagocytosis receptor exprssed on macrophages . Also scavenger receptors that bind to anionic polymers found on pathogens. Sialic acid on normal cells sheields slef molecules from scavenger. In addition to facilitating eliminating also removal of old proteins and cell as sialic acid gradually gets degraded away, reveals underlying carbohydrates that can be recognized by scavenger receptors. Signalling receptors main class to be discussed.
