IMM250H1 Lecture : Lecture notes
Document Summary
Innate immune system has developed strategies different from adaptive immune system to protect against infection. Innate immune system links many places with adaptive immune system. He observed there were cells he called phaogcytes that had capacity to physically engulf invading things. Not passive defense mechanism cells observed to migrate to site of injury and were once there, appeared to be moving, physically surrounding invading particle. In context of other work done at time when von behring discovered antibodies. Fundamental property of immune system was capacity to distinguish self and non-self. Acquire tolerance to self-antigens, allowing everything else to be considered foreign basis of self-non- self discrimination. Innate immune system also has capacity to distinguish between self and non-self but does so in. Modern understanding of innate immunity started with ex. Janeway who postulated that in microbial world, commonly expressed molecules .
