IMM250H1 Lecture Notes - Chemical Abstracts Service, Histone H2A, Anatta
Document Summary
Cdr1/2 and cdr3 loops from outer parts and center of the antigen binding site respectively. Epitopes often buried within native structure of tcr. Foreign peptide must be bound to mhc molecule. 1 and 2 form wall of cleft or groove where peptides bind. 1 and 1 form wall of wide cleft/groove where peptides bind. Binding groove is more open and can accommodate great variety. Peptide stabilized by shallow and deep pockets along cleft. Class i on all nucleated cells- more on immune cells. Human mhc also called hla (human leukocyte antigen) Haplotype: entire set of alleles for given region on single chromosome. Synegneic mice accept grafts due to identical mhc alleles. Allogenic mice reject grafts due to different mhc alleles. Gene conversion is a mechanism for generation of polymorphism. Misalignment of chromosomes favoured when many copies arrayed in tandem. Crossing-over and recombination enable exchange of genetic information. Stabilized by anchor residues that fit into mhc groove pockets.
