IMM350H1 Lecture Notes - Lecture 10: Erythropoietin, Stat1, Ifnar1
Document Summary
Affect many cells: signal differentiation, activation, ab secretion. Structural motif: four helix bundle in four antiparallel helices: il-2, il-4, il-3 have short helices of 8 10 amino acids, il-6, il-12 have long helices of. Signalling through hematopoietin receptors (and ifnrs) -> jak-stat pathway. Recruits stat (bind to sh2 domains) which becomes activated. Common feature is receptors have multiple subunits. Ex: il-2r: low, intermediate and high affinity forms based on accessory receptor chains. differentiation of effector cd4s by activating different transcription factors. Tregs have high affinity il-2 (cid:396)e(cid:272)epto(cid:396)s (cid:271)ut do(cid:374)"t p(cid:396)odu(cid:272)e (cid:373)u(cid:272)h. X-linked scid caused by mutation is gene encoding -chain: -chain bearing family. Proliferation and maturation of precursors in bm: ea(cid:272)h (cid:272)ytoki(cid:374)e (cid:271)i(cid:374)ds u(cid:374)i(cid:395)ue unit, is shared transduction protein, makes it high affinity, redundancy: stimulate blood cell differentiation (il-3 and. Gm-csf on hsc & early progenitors: activate granulocytes (eosinophils/basophils) Secreted by: dcs, macrophages, virally infected cells.
