IMM350H1 Lecture Notes - Lecture 9: Interleukin 18, Map3K7, Inflammasome
Document Summary
Group 1: il-1 family (promote inflammation: includes il-1 , il-1 , il-1ra, il-18, Proteins fold into 12 stranded - barrel. Il-1 and il-18 have pro domains at amino termini that need inflammasome to active: nlrp3 inflammasome -> activates caspase 1 -> cleaves pro-il-1 and pro-il-18 to activate. Acts locally on capillary permeability, systemically signals liver to produce proteins & cytokines, can activate adaptive immunity. Il-1 receptor activated kinases (iraks) recruit traf-6, tak1. Tak1 phosphorylates ikk leading to destruction of ikb. Pro-inflammatory molecules expressed: il-1 , il-1 trimmed 31 to. 17kda, bind to il-1ri/il-1racp: il-1ra binds to il-1ri and prevents it from binding to partner iracp (antagonist) Il-18: similar to il-1 (redundancy), uses same receptor family: also processed in secreting cells to become active, expressed early by macrophages/dcs, inhibition through soluble il-18 binding proteins that interfere with its binding to receptor. Il-33: constitutively expressed in smooth muscle: induces th2 cytokines that. B cells/mast cells/eosinophils: implicated in asthma, allergies,
