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Class Notes for Immunology at University of Toronto St. George

IMM340H1 Lecture 10: Lecture 10

IMM340 Lecture 10: Cytokines and Chemokines General Properties of Cytokines and Chemokines Cytokines are small proteins of less than 30 kDa that mediate the effector functions of the immune system and allow cell communicat...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture 9: Lecture 9

IMM340 Lecture 9: B Cell Activation and Antibody Production The Humoral Immune Response: Activation of B cells and Antibody Production Nave Mature B cells express IgM and IgD o Recognize antigens in native form (directly) ...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture 4: Lecture 4

IMM340 Lecture 4: Antibody Structure and Function Introduction Immunization of an animal with an infectious agent like a bacterium, virus or some sort of pathogen causes an immune response to be generated in the animal to ...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture 8: Lecture 8

IMM340 Lecture 8: T Cell Activation, Differentiation, and Functions T Cell Circulation Nave lymphocytes constantly circulate in the body o They do this in the blood supply (arteries and veins) and in the secondary lymphoid...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture 6: Lecture 6

IMM340 Lecture 6: Antigen Recognition by T Cells Interactions between T cells and their antigens Antigen specificity and their differences MHC molecules and the type of antigens that they present What are the co-receptors ...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture Notes - Lecture 7: T-Cell Receptor, Memory T Cell, Fragment Antigen-Binding

Lecture 7.1: T-Cell Receptor and Proteins T Cell Receptor Structure The TCR is a heterodimeric protein Protein structure of this molecule was very quickly characterized TCR has the and chains both of which are transmembran...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture 5: Lecture 5

IMM340 Lecture 5: Antibody Genetics Antibody Diversity 2 junctions in the heavy chains V to J sequence and then VJ to D sequence Increase the junctional diversity o 30 million combinations for any particular junction Molec...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture Notes - Lecture 3: Complement System, C1 Complex, Complement Factor B

IMM340 Lecture 3: The Complement System The Complement System A collection of proteins that respond to pathogens through three effector arms that produce inflammation, enhance phagocytosis of microbes, and lyse microbial m...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture Notes - Lecture 2: Pathogen-Associated Molecular Pattern, Pattern Recognition Receptor, Innate Immune System

IMM340 Lecture 2: Innate Immunity Innate Immune Responses Proceed in a Series of Steps Inflammatory Inducers o Bacterial lipopolysaccharides, ATP, urate crystals o Signs of infection or cellular damage (PAMPs or DAMPs) Sen...

Immunology
IMM340H1
Liliana Clemenza
IMM340H1 Lecture 1: Lecture 1

IMM340 Lecture 1: Overview of the Immune System The Immune System The immune system is broadly a system that is comprised of the three components of the body tissues, cells, and molecules o Tissues Bone Marrow where immune...

Immunology
IMM340H1
Liliana Clemenza
IMM250H1 Lecture Notes - Lecture 8: Antimicrobial Peptides, Dendritic Cell, Microvillus
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Lecture 8 - GI tract immunity Mucosal system need to determine whether antigen id innocuous or harmful physiologic information (low level) that System activates dendritic cells trigger adaptive immunity At mucosal: recruit...

Immunology
IMM250H1
Liliana Clemenza
IMM250H1 Lecture Notes - Lecture 9: Upper Respiratory Tract Infection, Orthomyxoviridae, Hpv Vaccines
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Lecture 9 - Emerging influenza variants and the case for improved vaccines Vaccination success Smallpox - 1979 eradicated Polio - next target MMP Rubella HPV Vaccine failure HIV TB Malaria Influenza Flu - infection with In...

Immunology
IMM250H1
Liliana Clemenza
IMM250H1 Lecture Notes - Lecture 5: Adaptive Immune System, Clonal Selection, Central Tolerance
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Lecture 5 - Generation of the Adaptive Immune Response Central tolerance process for self reactive lymphocytes mature Reduced repertoire is the functional receptors Review Naive: never encountered antigen Mature: encounter...

Immunology
IMM250H1
Liliana Clemenza
IMM250H1 Lecture Notes - Lecture 4: Lymph Node, Mast Cell, Natural Killer Cell
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Lecture 4 - The acute inflammatory response: Cellular and humoral mediators of innate defense Innate Cellular and humoral mediators Cells: phagocyte, mast cells, NK Mediator: cytokines, complement Cellular Phagocytes Macro...

Immunology
IMM250H1
Liliana Clemenza
IMM250H1 Lecture Notes - Lecture 1: Cowpox, Neutrophil, Apoptosis
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Lecture 1 - the immune system: from historical to modern perspectives Immune system A system of tissue, cells and soluble factors that recognize, attack and destroy Stages of response: Entry of pathogen recognition Varied ...

Immunology
IMM250H1
Liliana Clemenza

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