LMP299Y1 Lecture Notes - Lecture 9: Dexamethasone Suppression Test, Adrenal Tumor, Acth Stimulation Test
12 Apr 2013
School
Department
Course
Professor
Document Summary
Adrenal gland: small triangular shaped glands situated just above the kidney. The hormones of the adrenal glands are essential for survival (the adrenal gland also helps make the reproductive hormone) Adrenal consists of cortex (outside) and medulla (part of the sympathetic nervous system) Adrenal cortex consists of: zona glomerulusa (this is the most outer layer; aldosterone), zona fasciculate & zona. Acth (this is there driver of the cortisol synthesis. Cholesterol (this is the precursor for the steroid hormone) 17 oh" ase (this is the important enzymes for these 2 (cortisol and testosterone) Cortisol (it is also a counter regulatory hormone) physiology. 18 oh" ase this is the important enzyme for this one. Carbohydrate promotion of gluconeogenesis (this is the making of new glucose in response to hypoglycemia) in liver, reduction in glucose use and uptake by peripheral tissues (helps us save the glucose that we have) Protein increase of muscle proteolysis to release the proteins.
