LMP299Y1 Lecture Notes - Immunoglobulin Class Switching, Transforming Growth Factor Beta, Autoimmune Disease

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Exam: shek usually asks multiple choice questions; ni usually asks short answer questions; m asks short questions; multiple choice and some short answer. Everyone has autoimmune activity ex, in western blot lots of interaction of own leukocytes and own antibodies. Understand solid understanding know very well. Immunity is defense system strong immune response needed. Malignant tumours usually occurs past forty years old young people less likely to develop tumours typically due to stronger immune surveillance and elimination cell-mediated immune response decreases once reach particular age, allowing tumour development. Immune tolerance if not tolerant of certain antigens, have autoimmune disease have adaptive immune system. In short, need immunity and tolerance to be well balanced this balance in multiple layers the layers are not perfect, but in general, it"s fine. Innate immunity same is not identicial but in general the same. Broad diversity t cell and b cell have large repertoire. B cell plasma mediated antibody generation humoral response.

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