LMP299Y1 Lecture Notes - Disseminated Intravascular Coagulation, Cytokine Storm, Robo4
16 Dec 2013
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If appendix bursts bacteria toxin access to circulation; inflammatory cytokines important in initial phase of sepsis get access to circulation that"s why get systemic effects. Correlation between sepsis in humans and animal model s. It is a disease of aged, though young people can get sepsis but have much better prognosis. Other concurrent illnesses that severely compromise their health and make outcome much worse. So mortality rate is very high in severe sepsis. Fda only approved activated protein c zymogen must be activated proteolytically. It is an inhibitor of factor 5 and factor 7 in the clotting cascade and alos has effects on endothelial receptor known as protein c receptor, which can be cytoprotective effects. Sepsis into several different categories do not memorize this. Different degrees of sepsis starting from the systemic inflammatory response; basically have fever and. Wbc count applicable to any infection, some leakage of inflammatory mediators such as il-1 and il-6.
