LMP363H1 Lecture Notes - Lecture 4: Elastase, Portal Triad, Adenocarcinoma
14 Sep 2016
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Document Summary
Between the single cell plates of the hepatocytes are sinusoids, endothelial cells, ito cells, and kupffer cells. Blood and bile flow in opposite directions. Basal site faces canaliculus: endothelial cells separate sinusoids from hepatocytes, stellate (ito) cells store fat and vitamin a, kupffer cells - phagocytosis, sinusoids blood flow. 75% from portal vein (nutrient-rich) and 25% from hepatic artery (oxygen-rich) Hepatic triad: portal vein, hepatic artery, bile duct. From the portal triad (zone 1) to the central vein (zone 3) Zone 3 has high p450: canaliculi bile flow. Exported as lipoproteins (triglycerides + cholesterol + phospholipids + apolipoproteins) Fatty liver caused by dysregulation/inhibition of lipoprotein synthesis. Caused by alcohol, diet, and chemical exposure: carbohydrate metabolism and glycogen synthesis, bile and protein synthesis, endogenous and exogenous detoxification. Conversion of fat-soluble toxins to water-soluble products for excretion. Zone 1 susceptible to phosphorus and allyl alcohol. Zone 3 susceptible to ccl4 and apap: fibrosis.
