LMP410H1 Lecture Notes - Lecture 3: Dorsal Nucleus Of Vagus Nerve, Synuclein, Substantia Nigra
31 Mar 2016
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Characterized by james parkinson in 1817 age related prety rare early onset is usually geneic but not necessarily mortality not due to the disease but is due to secondary efects levodopa (l-dopa) is a drug used to treat pd. Aeiology mptp users infecing people in the 80s, they are used to create mouse models for. Pd pseudoparkinsonism has features of parkinsonism but completely diferent to that of pd idiopathic is sporadic (no family history) vs familial which is passed down from family members. Remember clinical features as progressive as ad and demenia lewy bodies present in the substania nigra and pars compacta made of -synuclein disrupts certain neural networks: lewy bodies inclusion bodies . Can be stained for protein markers like those listed on the slide we don"t understand why they form, how they form etc assume that the neurons put toxic substances in these bodies but overime they can become a problem.
