LMP299Y1 Lecture Notes - Chimeric Antigen Receptor, Tumor Microenvironment, Pd-L1
3 Jun 2013
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Degenerates into disease with different cellular organisms but similar hallmarks cancer cells develop insensitivity to that encourage own blood supply can grow indefinitely. For a cell to grow indefinitely glycolysis fatty acid oxidation all hallmarks of cancer. Immune system arose to deal with viral infections but principal same for cancer. Also cause systemic gvh disease so the idea was that in patients, mimic gvh and get the therapeutic effects of the gvh. One has to use a donor that is quite closely matched at the hla loci the best donor would be family member of sibling . Ac ad bc bd four siblings if ac has cancer, but the other three are not eligible to donate. High age and low likelihood of elibible matched sibling so low chance. Minor antigens would serve as source of antigen to drive gvh disease so mud transplants still toxic because can induce gvh disease.
