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LMP410 - September 11, 2013.docx

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Laboratory Medicine and Pathobiology
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LMP410September 11 2013Each quiz is one percentten quizzes one per lecturefive minuteson what was just heard Midterm is worth 40only up to ALS lecture Final exam is from ALS lectureNOT CUMULATIVEUnderstand what you are hearingso can apply to question Neurodegenerative Diseases Common properties and strategies A neurodegenerative diseaseaffects braindeterioration of specific subset of neurons Divided into two different groupscausing problems with motor functionthe other affects memory This division is the classical definition Classified by protein that is toxic accumulates in brain and spinal cord Repeat expansion of glutaminestoxic to proteinsAmyloid depostited extracellularly Tauopathiestau protein structural protein ALSMSdemyelinating diseasesee sclerotic plaques multiple plaques hence name Less common diseaseswill hear a little of these If patient goes to see doctor get diagnosis of neurodegenerative diseaseit is a PROBABLE diagnosis Only definitive when look at postmortem examination Alzhemiersprobable diagnosis onlycan only be confirmed by neuropathologists after eath Clinicalcan be attributed to many different things the symptomsclinician uses rational deductionnarrow down Imaging techniques get betterMRI imaging sees structure of brain Second to understanddiseases motor vs memory is classical definitionthey are highly heterogenous and motor disturbances in Parkinsons patients can towards the end have dementia Pure alzheimers disease can also have motor problems in the end too Common features All age relateddo not normally see neurodegenerative diseases in young people Usually in aging population of forty and above Pathological characteristicsneuronal death and in each disease the primary neuronal pathway that diengerates is specific to that disease Second pathological characteristicamyeloid formationmisfolded protein or on the other side get inclusion bodies within the cellmisfolded proteins that accumulate and cause toxicity And all of the diseases have an inflammatory component No known cureand all diseases are lethal All neurodegenerative diseases start in braincan affect central and peripheral functionALS starts in the brain for degenerationbut degeneration of motor neurongoes into peripheral nerves as wellstart in the brain but can also affect the peripheral neurvou system as well
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