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Lecture 15

LMP301H1 Lecture 15: Calcium

by OneClass328331 , Winter 2016
3 Pages
29 Views
Winter 2016

Department
Laboratory Medicine and Pathobiology
Course Code
LMP301H1
Professor
all
Lecture
15

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LMP301
Introduction to the Biochemistry of Human Disease
Lecture 15 Calcium
Homeostasis
o Net gain at intestine = net loss at kidney (150 mg/d)
o No net change at bone formation/resorption (500 mg/d)
Hormones
o PTH
Produced by the parathyroid glands behind the thyroid
Stimulated by low serum Ca2+ and inhibited by high Ca2+
Bone: bone resorption
Kidney: Ca2+ reabsorption, PO4- reabsorption
Stimulate 1,25 (OH)2 vitD
o 1,25 (OH)2 vitD
Plants: from vitD2; Animals: from vitD3
ProvitD3 vitD3 25-OH D3 1,25(OH)2D3 (active)
Side products: 24,25(OH)2D3 and 1,24,25(OH)3D3 (inactive)
1st step: UV
2nd step: 25-hydroxylase (liver)
3rd step: 1α-hydroxylase (kidney, pancreas, etc.)
Inactivation: 24-hydroxylase
Autocrine: regulation of cell growth
Paracrine: immune modulation
Endocrine: calcium homeostasis, muscle and bone health
Intestine: Ca2+ and PO4- absorption
Bone: ↑ bone resorption
Feedback: inhibit PTH
Bound to vitD-binding protein in circulation and targets nuclear vitD
receptor
o Calcitonin
From the parafollicular/C cells of the thyroid
Stimulated by high Ca2+, gastrin, and pentagastrin
Inhibit bone resorption by osteoclasts and Ca2+ and PO4- (clinically
insignificant)
Treatment of osteoporosis
Marker of medullary thyroid carcinoma (C cells)
Bone
o Osteoclasts (resorption) and osteoblasts (formation)
Resorption markers: deoxypyridinoline
Formation markers: alkaline phosphatase, osteocalcin
Diseases
Name
Causes
Characteristics
Diagnosis
Treatments
Hypocalcemia
Idiopathic
Post-surgical
Pseudohypoparathyroidism
Neuro-
hyperexcitability
(tetany,
serum Ca2+

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Description
LMP301 Introduction to the Biochemistry of Human Disease Lecture 15 – Calcium  Homeostasis o Net gain at intestine = net loss at kidney (150 mg/d) o No net change at bone formation/resorption (500 mg/d)  Hormones o PTH  Produced by the parathyroid glands behind the thyroid  Stimulated by low serum Ca and inhibited by high Ca 2+  Bone: ↑ bone resorption  Kidney: ↑ Ca reabsorption, ↓ PO rea4sorption  Stimulate 1,25 (OH) 2itD o 1,25 (OH) 2itD  Plants: from vitD2; Animals: from vitD3  ProvitD 3 vitD 325-OH D  1,35(OH) D (act2 3)  Side products: 24,25(OH) 2 3nd 1,24,25(OH) D 3 3active) st  1 step: UV  2 step: 25-hydroxylase (liver) rd  3 step: 1α-hydroxylase (kidney, pancreas, etc.)  Inactivation: 24-hydroxylase  Autocrine: regulation of cell growth  Paracrine: immune modulation  Endocrine: calcium homeostasis, muscle and bone health 2+ -  Intestine: ↑ Ca and PO ab4orption  Bone: ↑ bone resorption  Feedback: inhibit PTH  Bound to vitD-binding protein in circulation and targets nuclear vitD receptor o Calcitonin  From the parafollicular/C cells of the thyroid  Stimulated by high Ca , gastrin, and pentagastrin  Inhibit bone resorption by osteoclasts and ↓ Ca and PO (clinically 4 insignificant)  Treatment of osteoporosis  Marker of medullary thyroid carcinoma (C cells)  Bone o Osteoclasts (resorption) and osteoblasts (formation)  Resorption markers: deoxypyridinoline  Formation markers: alkaline phosphatase, ost
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