Class Notes (887,227)
CA (530,971)
UTSG (45,527)
LMP (74)
LMP301H1 (8)
all (8)
Lecture 15

LMP301H1 Lecture 15: Calcium

3 Pages
29 Views

Department
Laboratory Medicine and Pathobiology
Course Code
LMP301H1
Professor
all

This preview shows page 1. Sign up to view the full 3 pages of the document.

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
LMP301 Introduction to the Biochemistry of Human Disease Lecture 15 – Calcium  Homeostasis o Net gain at intestine = net loss at kidney (150 mg/d) o No net change at bone formation/resorption (500 mg/d)  Hormones o PTH  Produced by the parathyroid glands behind the thyroid  Stimulated by low serum Ca and inhibited by high Ca 2+  Bone: ↑ bone resorption  Kidney: ↑ Ca reabsorption, ↓ PO rea4sorption  Stimulate 1,25 (OH) 2itD o 1,25 (OH) 2itD  Plants: from vitD2; Animals: from vitD3  ProvitD 3 vitD 325-OH D  1,35(OH) D (act2 3)  Side products: 24,25(OH) 2 3nd 1,24,25(OH) D 3 3active) st  1 step: UV  2 step: 25-hydroxylase (liver) rd  3 step: 1α-hydroxylase (kidney, pancreas, etc.)  Inactivation: 24-hydroxylase  Autocrine: regulation of cell growth  Paracrine: immune modulation  Endocrine: calcium homeostasis, muscle and bone health 2+ -  Intestine: ↑ Ca and PO ab4orption  Bone: ↑ bone resorption  Feedback: inhibit PTH  Bound to vitD-binding protein in circulation and targets nuclear vitD receptor o Calcitonin  From the parafollicular/C cells of the thyroid  Stimulated by high Ca , gastrin, and pentagastrin  Inhibit bone resorption by osteoclasts and ↓ Ca and PO (clinically 4 insignificant)  Treatment of osteoporosis  Marker of medullary thyroid carcinoma (C cells)  Bone o Osteoclasts (resorption) and osteoblasts (formation)  Resorption markers: deoxypyridinoline  Formation markers: alkaline phosphatase, ost
More Less
Unlock Document
Subscribers Only

Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
Subscribers Only
You're Reading a Preview

Unlock to view full version

Unlock Document
Subscribers Only

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit