LMP301H1 Lecture Notes - Lecture 19: Aldehyde Dehydrogenase, Codeine, Hydrophile
14 Sep 2016
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I"(cid:373) slightl(cid:455) i(cid:374)to(cid:454)i(cid:272)ated (cid:396)ight (cid:374)o(cid:449) so e(cid:454)(cid:272)use the typos and comments (profanity might be involved) Biotransformation (mostly liver: convert lipophilic to hydrophilic molecule aids in elimination. Reduction, oxidation, hydrolysis, conjugation: phase i by p450s (which are inducible, inhibitable, and genetically polymorphic) Elimination mainly by kidney (some intestine via bile, also breath, saliva, breast. Case study: codeine (cid:894)do(cid:374)"t take this (cid:449)hile d(cid:396)u(cid:374)k, like (cid:373)(cid:455) f(cid:396)ie(cid:374)d did, (cid:271)ut she su(cid:396)(cid:448)i(cid:448)ed tha(cid:374)kfull(cid:455)(cid:895) milk but not for men: metabolized by cyps (2d6) o-demethylation morphine (3a4) n-demethylation norcodeine. Intestinal permeability endotoxins kupffer and immune inflammation and stellate (fibrosis) = rip liver xp. Slide (cid:1006)(cid:1009) (cid:894)do(cid:374)"t (cid:395)uote thi(cid:374)gs (cid:455)ou do(cid:374)"t k(cid:374)o(cid:449)(cid:895: synthetic derivative of meth (cid:894)i"(cid:373) (cid:374)ot high, just d(cid:396)u(cid:374)k. i do(cid:374)"t k(cid:374)o(cid:449) (cid:449)he(cid:396)e to get (cid:373)eth anyway) I hope (cid:449)e do(cid:374)"t (cid:374)eed to (cid:373)e(cid:373)o(cid:396)ize this shitt(cid:455) ta(cid:271)le. I hope my (cid:271)od(cid:455)"s (cid:1006)e(cid:1005) is (cid:449)o(cid:396)ki(cid:374)g (cid:396)ight (cid:374)o(cid:449).
