LMP363H1 Lecture Notes - Lecture 2: Prostaglandin, Dysplasia, Autocrine Signalling

• School: UTSG
• Department: Laboratory Medicine and Pathobiology
• Course: LMP363H1
• Professor: all

Document Summary

I(cid:374)(cid:272)ludes su(cid:373)(cid:373)ary of te(cid:373)pleto(cid:374)"s se(cid:272)tio(cid:374) + lee"s se(cid:272)tio(cid:374) Pathobiology is the response of the cell to changes in the environment, be it external or internal. Response of the cell and tissue to injury. The four hallmarks of adaptive responses are: expressed on demand, reversible when demand ceases, survival advantage, cause minimal disturbance in homeostasis. General responses include heat shock proteins and ubiquitin. Necrosis coagulative, liquefactive, hemorrhagic, caseous, contraction band. Superoxide - o2 created by electron transport, nadph oxidase, and xanthine oxidase. Hydrogen peroxide h2o2 created spontaneously from superoxide, sod, and peroxisome oxidases. Hydroxyl oh created by fenton reaction, haber-weiss reaction, and ionizing radiation. Oxidative damage can lead to dna damage and lipid peroxidation. Reperfusion injury occurs when blood supplying oxygen returns to tissue after a period of ischemia. Calcium paradox occurs when hypocalcemia smooth and cardiac muscle cells die when re-exposed to normal levels of ca2+. Apoptosis and necrosis differ in physiological, histological, morphological, and biochemical features.