MGY250H1 Lecture Notes - Lecture 1: Diabetes Mellitus Type 2, Yeast Artificial Chromosome, Progeria

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Unit 1: Perspectives on Medical Genetics
Introduction to Medical Genetics
Chronic Myeloid Leukemia (CML)
- Cancer transformed by treatment
- Chemotherapy is only 30% effective
- Gleevcc -> survival after 5 years = 95%
- 2001- Gleevec approved by FDA in USA
o For treatment of CML
o Unlike chemotherapy drugs, which target fast
growing cells unspecifically, Gleevec functions
by targeting cancer directly
-
Genetics Impacts Many Aspects of Human
- Ex: Determining genetic that increases risk of depression from dataset of ~85 000 people with
depression
- Important to understand genetics in diseases
o Can understand how diseases manifest, how to diagnose and treat early, how to live
well for longer period of time, etc.
- E.g. prenatal diagnosis
Leading Causes of Death in Canada
- Have genetic component
- Top 2 killers (cancer and heart disease) -> genetic
factors play a role
- Genetic susceptibility interacts with environment
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