MGY378H1 Lecture Notes - Virus, Chromatin, Nuclear Pore
3 Jun 2013
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Virion: adenovirus virion icosahedral bigger than parvoviruses, made up of hexons and pentons hexons on flat surface, pentons at vertices, pentons have base and fibre that sticks out. Fibres of different lengths diagnostics of subtypes. Terminal protein yellow square at each end covalently linked to dna packaged with dna. Protein seven like histones adenovirus forms chromatin like structure uses own protein to do that associated with whole length of genome protein ten not much known about. Four proteins five, seven, and ten and terminal protein. Seven is major core protein that forms histone like centres viral dna can wrap around them resembles nucleosomes . Linear genome have ds break cell will try to repair that. If not linear genome coming into cell ends resemble ds break mechanisms to stop from being ligated together. Linked to five prime end terminal proteins. Genome has inverted terminal repeats 100 nucleotides at each end.
