07 - bunya.docx

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Bunyaviridae
- Negative strand RNA viruses
- Tospovirus will not be discussed
- Generally arboviruses
LaCross encephalitis
- Younger than 16 because kids tend to be more adventuratous in environment - so more
susceptible to being bitten
- Mosquito bites chipmunck or squirrel, virus grows, mosquito bites this, cycle continues
Symptoms
- Vary
- Like polio only small minority of people display disease
- Those that do can have marked impact
- Can replicate in brain - seizures
- Camping trips, summer camps pick up this
- Can recover from infection but those that experience encephalitis and seizures are left
susceptible to recurring seizures and epilepsy
- F
Rift Valley fever virus
- Livestock affected
- Aerosolized blood
o Rare but source from butchered animal
- Can be transmitted in humans
o Liver
- Distribution predominantly Africa
Crimean-Congo HF
- Ticks
- Induces localized hemorrage
Hantavirus
- Exception in the same class but different mode of transmission
o By inhalation of rat feaces or urine
- Mouse to mouse how maintained
- Coevolution of virus and host species
o Mouse unharmed despite high titres in blood
Transmission vectors
- Mice where rodents are, hantaviruses are
Two types of outcome depending on strain infected with
- Renal syndrome Korean war soldiers
o Messy living, rats follow soldiers, leaving food crumbs
- Pulmonary syndrome
o Targeting lungs
o Mass inflammatory response in lungs
o Lungs fill with fluid, drown
o HIGH mortality rate
o Dramatic change in average rain fall explosion in deer mice population
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