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MGY378H1 Lecture : 08 - influenza - notes.docx

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redtermite204
25 Apr 2012
School
UTSG
Department
Molecular Genetics and Microbiology
Course
MGY378H1
Professor
Alan Cochrane

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Document Summary

If have flu bedridden; have corona or rhino virus sniffling nose. Cytokine storm basis of massive death in 1918 spanish flu. Humans can carry the infection and infect other humans. Vaccination best not preventing infection but speeding recovery from infection **** Will probably get infected but no clinical manifestations if get vaccinated. Also young children included 0 also at risk. Current vaccine is killed virus 75% effective. Survey what"s circulating in year, choose three most dominant strains grow in chicken eggs vaccine making is time consuming. Live attenuated grows in nasal passages, having been adapted to grow at 33degrees not 37 no needles. Moved so fast and so broadly thus concern. Epidemic appeared to initiate in mexico and texas (south) Swine flu called so because h1n1 came from flu seen in pigs or closely resembled it. Ha, np, na - hemaglutinatin, np is rna binding part of virus, na is neuraminadase. M1 spliced to produce m2; ditto with ns2.

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