MGY299Y1 Lecture Notes - Long Non-Coding Rna, Copy-Number Variation, Rna-Seq
3 Jun 2013
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Document Summary
Idea of what is an individual is still not addressed. Sequences generated from individuals ventor from private effort to sequence. Multiple emergence from africa ot of africa, through middle east, india, australia from sequence analysis, clear that out of africa has occurred multiple times, with multiple routes. Individual sequences from recent hominin relatives lots of interesting results. Older humans hominin difficult to get high-quality dna keep in cold and prevent bacterial growth are important to preserve dna. More ancient humans difficult to find enough high-quality dna sequences to. Essentially 90% of genome involves effort to do this very intensive bioinformatics analysis. Most of the variation in human genonme is not in exons if want to understand variation in sequence, this method will miss some variation. New generation chromosome maps capture breadth of genetic variation copy number variant information; know alternate sequences (regions in genome like immune response genes that vary between individuals want to know when different, how different)
