MGY377H1 Lecture Notes - Lecture 32: Cycloserine, Bacitracin, Tetracycline Antibiotics
1 Feb 2018
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Penicillin stops peptidoglycan from being synthesized, and all bacteria have and need peptidoglycan to sur(cid:448)i(cid:448)e. this is (cid:449)hy pe(cid:374)i(cid:272)illi(cid:374) does(cid:374)"t atta(cid:272)k us, (cid:271)ut atta(cid:272)ks (cid:271)a(cid:272)teria. They all have the same lactam ring which is important for blocking trnspeptidases, and they also have derivatives on other parts. If we have a drug with minor alterations, it can work on different species or a resistant strain. The drugs are getting slightly more complicated each time. The active site for this drug stays the same. The (cid:448)ariatio(cid:374)s o(cid:374) the outside so(cid:373)eti(cid:373)es allo(cid:449) the drug to do thi(cid:374)gs it (cid:272)ould(cid:374)"t do (cid:271)efore. Drugs have to work against the ezyme, they have to inhibit it, and they have to work efficiently and be able to get into the organism they have to inhibit. Thus they have to get thru cell walls and membranes. Varying parts of the drug that are(cid:374)"t spe(cid:272)ifi(cid:272) for the activity can broaden its specificity.
