13 - TT1 review.docx

3 Pages
Unlock Document

University of Toronto St. George
Molecular Genetics and Microbiology
Alan Cochrane

MGY378 – Feb 6 Noon to one – McCaul – EX100 – multiple choice questions – 30 questions – 3 per lecture - If discussed in lecture, then KNOW IT - If not discussed but in lecture, ignore How do they replicate? How do they damage you? What diseases caused by which family? Symptoms – graphic deaths – know Five M/C are none of the above Which of the following statemtents is incorrect regarding he transmission of viruses within a population? - Poliovirus transmission ivolves the absorption of the virus by the intestional tract - Influenza virus is transmitted through aerosols - African horse sickness virus is transmitted via the oral fecal route – WRONG – transmitted by insect bites - Yellow fever is transmitted via insect bites Which of the following statemtns is incorrect regarding poliovirus replication? - Virus particle lacks lipid envelope - RNA genome has a protein covalently attached to 3’ end of rNA - Infection by poliovirus results in shut off of host mRNA translation due to cleavage of ElF4G - Addition of two U residues to Vpg is required for the priming of + strand RNA synthesis - BBBBB Which of the following statemtns is correct regarding rhe replication of flaviviruses? - Most flaviviruses genomic RNA lack a 5’ cap - Viral RNA is translated as a polyportein in the cytoplasm - prM protein functions to block the fusion activity of the E protein - virus entry occurs via direct fusion with the plasma membrane - CCCCCCCCCCCCCCC – conserve fusion activity of E until it gets out of the cell Which is the most frequently transcribed and translated gene in Coronoaviruses? - Membrane - Spike - Pol (replicase transcriptase complex) - Nucleocapsid - Envelope - DDDDDDDDDDDDDDDDDDD Amantadine is an antiviral - Effective against influenza A, B, and C - Blocks M2 of influenza A only - Inhibits the release of new influenza A virions from infected cells - Inhibits RNA polymerase of orthomyxoviruses - Interferes with HA binding to its receptor to prevent infection - BBBBBBBBBBBBBBB – M2 required for acidification because needed for release of genome into cytoplasm o Influenza A is the most virulent – so want to target this o M2 is ion pump so involved in acidification Wht is ambisense coding strategy that is used by bunyaviridiae? - Transcription of mRNA from both genomic rNA and antigenomic RNA - Transcription of mRNA from genomic RNA strand in two different directions - Translation of a single mRNA bidirectionally - A single gene that is made into a on functional and functional protein - A gene that is tanscribed into one protein when replicating in the invertebrate host and into a different one in the vertebrate host What is the theoretical maximum number of NEW progeny (excluding the parent pair) of genetic reassortment in bunyaviridae? - 6 = 2^3 because three segments subtract parental, so SIX Which of the following statements is incorrect regarding flioviruses - Infection in duces vascular leakage due to diss
More Less

Related notes for MGY378H1

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.