MGY378H1 Lecture Notes - Enfuvirtide, Chemokine Receptor, Croatian Radiotelevision
3 Jun 2013
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Ci index lower the better lower, more effective the drug amount of drug used. Delivery delivered to site where needed in active form not be metabolized. Drug a and b calculate the ci value drug a is more ffective gives lower ci index. Costly to develop stages of research, so long time of development also some drugs may never make it to the marketing stage. At the end of the stages, very few make it through. 1- both alpha herpes viruses acyclovir inhibits. 2- do in vitro assay inhibit activity in test tube. 3- screen for expression of gene that block. 4- structure based approach have structure of viral protein, and can look at it and figure out ways to inhibit it to design chemicals that fit in critical pocket of proteins typically enzyme, Inhibitors can work at any stage of infection.
