MGY378H1 Lecture : Notes taken during lecture

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Lot of dsrna genomes reoviridiae virsues isolated in 1950s from kids and. Infect range of species humans, insects, plants, yeast quite diverse in what they challenge. Reoviridae top three what will be discussed. Orthorevoviruses respiratory enteric can isolate from either respiratory tract or gut. Called orphan viruses b/c in humans, no pathology definitely not lethal. Coltiviruses have rare cases where caused disease in humans. Actually two concentric shells outer and inner provides stability in env that not normally. Shells treat virion with partial proteolysis get intermediate subviral particle, chew back more, get viral core. This virus seen in wild isolated from multiple sources. Ingested contaminated foods, soil etc infected this way: virion uninfective fairly, nust be processed into intermediate to be infectious, but if proteolysed into core, becomes non infectious again. three of l coding for lambda proteins. three of m that code for mu proteins. small four of code for four sigma proteins.

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