MGY440H1 Lecture Notes - Antigenic Shift, Reoviridae, Reassortment
3 Jun 2013
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Document Summary
Kuss et al science paper - enteric microbiota. Two strains of mice, pvr and pvr ifnar. Mixture of four antibiotics - different mechanisms, target different groups of bacteria. C - same effect regardless of whether treated with antibiotics or not - D - antibiotic-treated mice had higher titres in feces - dashed line is not. For the antibiotic treated mice, took longer to pass the dye - gut. Percent replication = (light insensitive = progeny only)/(unexposed = Antibiotic treated mice, little replication in feces. F - surprising - untreated mice - almost same amount of replication as. Cns - in the gut, not as important to have interferon. Perhaps only need interferon to prevent dissemination from gut to the. Interferon not a large impact on viral replication - but the virus. Part c - protection lost because have antibiotic resistent bacteria in gut. Part d - virus replication is higher than antibiotic-treated mice for mice given antibiotic resistent bacteria.
