NFS284H1 Lecture Notes - Lecture 14: Menopause, Prostate Cancer, Adipose Tissue
16 Nov 2016
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Nov 16 lecture - energy balance and weight. Obesity and cancer: observational studies, the cancers with the most research attention (colorectal and breast) Prostate cancer has not been shown to be correlated to obesity. Obese patients may not respond to treatment as well as their lean counterparts. The cell de-differentiates stop functioning as their own cells and just become rapidly growing (proliferative) cells: they do(cid:374)"t respo(cid:374)d to (cid:374)or(cid:373)al sig(cid:374)als that (cid:272)ells ha(cid:448)e. Apoptosis is the ultimate step that the cell takes to get rid of damaged cells: completely kills the cells, but this does(cid:374)"t happe(cid:374) i(cid:374) (cid:272)a(cid:374)(cid:272)er. Insulin and estrogen: promote cell growth (healthy or unhealthy cells) Estrogen circulates in the blood bound to protein. When it is circulating in free form it is more of a stimulant to cell growth. In the liver the shbg decreases and increases free estrogen. Increases adipose tissue mass: site of estrogen synthesis.
