PCL102H1 Lecture Notes - Lecture 6: High-Throughput Screening, Broad Institute, Antimicrobial Resistance
1 Feb 2018
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Chemist and geneticist at broad institute and harvard med school and practising physician. Studied host-pathogen interactions to identify new approaches for treating infections. Dont know how something will act in a human / dont know what in vivo conditions are. But their immune system isnt alot like humans. Found that antibiotics will rescue the embryos when you infect them. But also found molecules that target the host which rescues them better when theyre added to the water. Less likely to generate resistance because human doesnt evolve as quickly as the bacteria. By modulating the host, you may have a better effect than simply killing the bug. If all animal models are limited in their ability to mimic whats going on in the human host, cant really figure out whats happening in humans.
