PCL102H1 Lecture Notes - Lecture 13: Molecular Mass, Insulin, Enzyme
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When the ligands acts on the molecules, the receptors comes together. When the receptor binds, it moves into the nucleus. When its unbinbed its inactive, when its binded its active. The drug has a shape that mimics the ligand. When the drug binds and blocks the ligand, it creates altered physiological responses. The produ(cid:272)ts don t fit as well as the su(cid:271)strate does. We are interested in these regions because these regions could predict protein changes, because they could give us a hint of where to start. We want to make drugs against drivers, because they drive the disease. Graph is organizing drugs by molecular weight, not many drugs are really small or really large. Most drugs that seem to wrk in people have a molecular weight of 200-500m. S the molecular are large and polar, they wont be able to cross barriers. The scores are how likely the molecules are to dissolve in different phases.