PCL102H1 Lecture Notes - Lecture 27: Forensic Toxicology, Tetraodontidae, Risk Assessment
Document Summary
All substances are poisons; there is none which is not a poison. Mechanisms reversible binding of a stable metabolite vs. irreversible binding of a reactive metabolite: exposure assessment how frequently are we exposed to it, acute: <24 hours, subacute: <1 month, subchronic: <3 months, chronic: 3+ months. Biomagnification: things at the top of a food chain accumulate toxins from its prey (mercury accumulation in tuna) Direct vs. indirect measurements: dose-response assessment at what dose does it become toxic. Graded dose-response curve: looking for intensity of effect. Quantal dose-response curve: looking for frequency of effect. In a threshold response, there is suddenly a point (threshold) where there is an effect. Therapeutic window indicates the relative safety of a drug = ld50 or: does not tell you the shape of the response curves. Csf = toxic/lethal dose to 1% of population/effective dose to 99% of. Td50/ed50 population: a and b have same ti, but drug b has a shallow slope and low.
